After a near-death scare involving a CIA bio-toxin, Francine decides to start a job as a realtor...making more money than Stan. Also, bumfighting!
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Hayley comes home with her hair dyed green, much to the dismay of Stan, who decides to cut it off while she is sleeping. To get Stan back, Hayley moves into her boyfriend's van and gets a job as a waitress at a strip club.
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After a forgotten anniversary leads Stan to submit Francine for memory erasure at the CIA, she reverts twenty years back instead of twenty minutes, becoming once again the wild child she used to be.
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Roger runs away after he and Stan have an argument. Once the CIA finds out, they organize a search team in order to find him and bring him in for questioning. So now Stan must either kill Roger or choose friendship over his career.
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When a new set of Iranian neighbors sends Stan off in a whirl of suspicion that leads to the destruction of Francine's block party, he must find a way to conquer the foreign threat and make it up to her at the same time.
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Stan goes to great lengths to compete against his rival, Chuck White, and become the new deacon of their church. Meanwhile, Steve is falling in love with Chuck's daughter, Betsy.
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Stan comes to terms with Steve being a geek when Steve helps him apprehend a cyber-terrorist. Meanwhile, Hayley helps Roger explore life outside the house.
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Stan gets stationed in Saudi Arabia and learns to love the Saudi lifestyle. Meanwhile, Hayley falls for a Saudi guy and Roger becomes a prince's concubine.
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Francine insists Stan and Hayley spend the day together so they can work out their differences. Her plan backfires when Stan takes Hayley to the National Gun Association Land, where their opinions about gun control drive them further apart.
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Steve becomes a famous author, and the entire family gets caught up in his celebrity, including Stan, who becomes an unbearable stage parent. After Steve hooks up with an agent, he abandons his family to lead a Cribs lifestyle.
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As Stan continues to dominate the household, Francine finds herself idolizing a group of women. She tries to impress them and even lies in order to gain acceptance into their group, until she realizes they aren't as perfect as they seem.
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After Stan and Roger have a rough day, they get into a fight that leads to a soul switch where they get a taste of life in each other's shoes. After the excitement stales, they face each other's problems.
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Stan seeks revenge for being the focus of a prank during his high school years by showing off that he married Francine, who was the homecoming queen. However, when her title is revealed to be a mistake, Stan goes out with the real queen.
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When Stan goes to Atlantic City for a bachelor party and is shunned by his so-called best friend, Roger steps in and becomes Stan's new sidekick. Their friendship goes to a whole new level, but when they return home and face Francine.
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Stan wants Steve to be popular and goes to desperate measures by giving him steroids to make him bigger, better, and part of the in-crowd at school.
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After Steve shows a lack of interest in Stan's job, Stan replaces him with Barry, Steve's obese friend, who is in fact malicious (without his medication) and plots to replace Steve completely.
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